Lithoplocamia lithistoides
http://pharmabiz.com/NewsDetails.aspx?aid=93751&sid=2 WebPM050489 is an effective polyketone inhibitor of Microtubule/Tubulin that can be isolated from Madagascan sponge Lithoplocamia lithistoides. PM050489 inhibits mitosis with an IC50 value of 26.4 nM. PM050489 has antitumor activity and can be used in cancer research [1] [2] . PM050489 inhibits the activity of HT-29, A-549 and MDA-MB-231 cells ...
Lithoplocamia lithistoides
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WebIsolation of PM050489 (1): The frozen specimen of Lithoplocamia lithistoides(61 g), collected by hand using SCUBA diving in Madagascar (S 17º 06.071' / E 49º 51.385') at a depth ranging between 6 and 20 m, was diced and extracted with H2O (3 x 200 mL) and then with a mixture of MeOH:CH2Cl2 (50:50, 3 x 200 mL) at 23 ºC.
Web1 dec. 2015 · PM050489 is a tubulin-binding agent originally isolated from the marine sponge Lithoplocamia lithistoides. This compound binds with very high affinity to β-tubulin at a new site, disrupting the microtubule network and impairing its function during divison, which leads to mitotic aberrations. Web11 dec. 2024 · At difference with the above cited phase II anticancer drugs, plocabulin (PM060184) is not an ADC but it is a Lithoplocamia lithistoides sponge-derived polyketide which acts as a very potent antimitotic agent, binding to a specific β-tubulin site with possible activity on tumors resistant to other tubulin inhibitors .
Web21 jan. 2024 · Kahalalide F has displayed potent cytotoxicity against cancer cells of the breast (BT-474, MCF7, MDA-231, and SK-BR-3), colon (HT29 and LoVo), liver (Hep G2), lung adenocarcinoma (A549), ovaries,... WebLithoplocamia lithistoides en Lithoplocamia · Bekijk meer » Unionpedia is een concept map of een semantisch netwerk organiseerde als een encyclopedie of een …
Web29 feb. 2016 · PM184 is a marine -derive drug found in a sponge called Lithoplocamia lithistoides. This drug candidate is a microtubule inhibitor that targets a protein called tubulin in a novel way. It blocks cancer growth by impairing cell division of tumour cells through the inhibition of a crucial process called mitosis.
WebLithoplocamia lithistoides adalah spesies spons yang tergolong dalam kelas Demospongiae. Spesies ini juga merupakan bagian dari genus Lithoplocamia dan famili … how many words is in 2 pagesWebLithoplocamia lithistoidesis 'n sponsspesiein die taksonomiese indeling van die Demospongiae(gewone sponse). Die liggaam van die spons bestaan uit kieselnaaldeen … how many words is my paperWeb17 mrt. 2024 · Plocabulin (PM060184/PM184, PharmaMar) is a compound of marine origin derived from the Madagascan sponge Lithoplocamia lithistoides. Plocabulin belongs to a family of tubulin-binding agents that inhibits tubulin polymerization by binding to the dimer’s end, with one of the highest known affinities among tubulin-binding agents. how many words is fahrenheit 451Webde Voogd, N.J.; Alvarez, B.; Boury-Esnault, N.; Carballo, J.L.; Cárdenas, P.; Díaz, M.-C.; Dohrmann, M.; Downey, R.; Hajdu, E.; Hooper, J.N.A.; Kelly, M.; Klautau ... how many words is mistborn book 1WebLithoplocamia lithistoides Dendy, 1922 (type by monotypy) Parent Plocamioninae Hooper, 2002 Orig. name Lithoplocamia Dendy, 1922 Synonymised names Monectyon Lévi & … how many words is in one chapterWebAn Lithoplocamia lithistoides in uska species han Porifera nga ginhulagway ni Arthur Dendy hadton 1922. An Lithoplocamia lithistoides in nahilalakip ha genus nga … how many words is neverwhere• Lithoplocamia atlantica (Lévi & Vacelet, 1958) • Lithoplocamia dolichosclera Lévi & Lévi, 1983 • Lithoplocamia indica Pulitzer-Finali, 1993 • Lithoplocamia lithistoides Dendy, 1922 how many words is peace talks dresden files