Flvcr2 heme
WebFinally, cells overexpressing FLVCR2 are more sensitive to heme toxicity, a finding most likely attributable to enhanced heme uptake. Tissue expression analysis indicates that … WebMutations in FLVCR2, a cell surface protein related by homology and membrane topology to the heme exporter/retroviral receptor FLVCR1, have recently been associated with Fowler syndrome, a...
Flvcr2 heme
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WebNM_017791.3(FLVCR2):c.543G>A (p.Val181=) AND Posterior column ataxia-retinitis pigmentosa syndrome Clinical significance: Benign (Last evaluated: Jan 12, 2024) Review status: 1 star out of maximum of 4 stars WebSep 7, 2010 · ABSTRACT Mutations in FLVCR2, a cell surface protein related by homology and membrane topology to the heme exporter/retroviral receptor FLVCR1, have recently been associated with Fowler syndrome, a vascular disorder of the brain. We previously identified FLVCR2 to function as a receptor for FY981 feline leukemia virus (FeLV).
WebHeme (iron-protoporphyrin IX) is an essential co-factor involved in multiple biological processes: oxygen transport and storage, electron transfer, drug and steroid metabolism, … WebFeb 8, 2008 · In human tissues, FLVCR is highly expressed at sites of high heme flux, including placenta, uterus, duodenum, liver, and cultured macrophages ( Fig. 3 ), which suggests that FLVCR prevents heme toxicity or facilitates heme iron trafficking in non-erythroid cells as well. Fig. 3. FLVCR protein levels differ in human tissues.
WebJan 5, 2015 · A recent in vitro study suggested that feline leukemia virus subgroup C receptor (FLVCR) 1β is the mitochondrial heme exporter, although the authors did not perform a direct transport assay.17Another study demonstrated that ATP‐binding cassette (ABC) B10, an inner mitochondrial ABC protein, participates in the export of ALA.18The … WebApr 20, 2024 · Altogether, these observations suggest that upregulation of other acute phase proteins during exercise training, such as Hpx, haptoglobin, and Flvcr2, can bind and transport heme to be metabolized by HO-1 intracellularly (Alonso et al., 2024; Schaer et al., 2014). For instance, in the absence of HO-1, but not Hpx, heme is highly toxic and ...
WebOct 12, 2024 · The prognostic marker FLVCR2 associated with tumor progression and immune infiltration for acute myeloid leukemia Acute myeloid leukemia (AML) is one of the most common hematopoietic malignancies in adults. The tumor microenvironment (TME) has a critical effect on AML occurrence, recurrence, and progression.
WebApr 1, 2013 · FLVCR2 is highly homologous to FLVCR1 and may function as a cellular heme importer. Mutations of SLC49A2 encoding FLVCR2 are observed in Fowler syndrome, a rare proliferative vascular disorder of the brain. The functions of the remaining members of the SLC49 family, MFSD7 and DIRC2 (encoded by the SLC49A3 and … chipmunk full movie youtubeWebApr 1, 2013 · FLVCR2 can be utilized by the FeLV-C variant FY981 to enter cells, indicating its expression on the cell surface (Shalev et al., 2009). In addition, in cell lines, FLVCR2 … chipmunk funnyWebNov 1, 2010 · Here, we report the cellular function of FLVCR2 as an importer of heme, based on the following observations. First, FLVCR2 binds to hemin-conjugated agarose, and binding is competed by free... chipmunk fun lyricsWebNM_017791.3(FLVCR2):c.839C>G (p.Pro280Arg) AND Posterior column ataxia-retinitis pigmentosa syndrome Clinical significance: Uncertain significance (Last evaluated: Apr 27, 2024) Review status: 1 star out of maximum of 4 stars grants for security cameras in schoolsWebMar 21, 2024 · FLVCR2 mutation is associated with Hydranencephaly. High-throughput sequence data identified mutations and a large deletion in the FLVCR2 gene casuing … chipmunk full mouthWebFlvcr2 Gene Detail Summary Symbol Flvcr2 Name feline leukemia virus subgroup C cellular receptor 2 Synonyms CCT, Mfsd7c, MGC:19050 Feature Type protein coding gene IDs MGI:2384974 NCBI Gene: 217721 Alliance gene page Transcription Start Sites 5 TSS Location & Maps more Sequence Map Chr12:85793313-85860359 bp, + strand From … chipmunk gasserWebKeel et al. (2008) also demonstrated that FLVCR mediates heme export from macrophages that ingest senescent red cells and regulates hepatic iron. Keel et al. (2008) concluded … chipmunk fun facts for kids