Csf2ra

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August undefined, 2024

Webcolony stimulating factor 2 receptor alpha subunit : Nomenclature updated to reflect human and mouse nomenclature: 1299863: APPROVED: 2016-01-20: Csf2ra : colony … WebTo facilitate the translation of PMT therapy to human hPAP patients, a self-inactivating (SIN) lentiviral vector was generated expressing a codon-optimized human CSF2RA-cDNA driven from an EF1α short promoter (Lv.EFS.CSF2RA coop ), and a series of nonclinical efficacy and safety studies were performed in cultured macrophage cell lines and ...

GM-CSF Receptor Alpha Chain (CSF2RA) Functions As a Novel Ligand

WebOct 21, 2024 · The expression of CSF2RA and IL1R2 in MAC sections was detected using antibodies of appropriate specificity (anti-CSF2RA, MBS711361; MyBioSource [San Diego, California, USA]; anti-IL1R2, LS-B377, LifeSpan [Seattle, Washington, USA]), and visualization system VECTASTAIN Elite ABC Kit (Vector Laboratories [Burlingame, … CSF2RA (Colony Stimulating Factor 2 Receptor Subunit Alpha) is a Protein Coding gene. Diseases associated with CSF2RA include Surfactant Metabolism Dysfunction, Pulmonary, 4 and Hereditary Pulmonary Alveolar Proteinosis.Among its related pathways are RAF/MAP kinase cascade and Interleukin-2 family signaling.Gene Ontology (GO) annotations related to this gene include signaling receptor activity ... pho holic stanton

CSF2RA colony stimulating factor 2 receptor subunit …

WebSep 20, 2024 · To test this, colony stimulating factor 2 receptor alpha (Csf2ra) knockout (KO) mice that lack GM-CSF signaling and wild-type (WT) mice models of intratracheal … WebHuman Gene CSF2RA (uc004cpp.2) Description: Homo sapiens colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) (CSF2RA), transcript variant 3, mRNA. RefSeq Summary (NM_172246): WebThe colony stimulating factor 2 receptor alpha (Csf2ra) gene encodes GM-CSF receptor a (CD116) in mice. Defective GM-CSF receptor signaling results in abnormal development and functionality of how do you become strong

JCI Insight - Gene therapy of Csf2ra deficiency in mouse fetal …

Gene therapy of Csf2ra deficiency in mouse fetal monocyte

WebJun 1, 2024 · To address the role of GM-CSF receptor signaling in the pathogenesis of chronic airway inflammation in vivo, we used Csf2ra −/− mice, which were transplanted … WebCSF2RA, colony stimulating factor 2 receptor subunit alpha Vertebrate Orthologs 2 Vertebrate Orthology Source. Alliance of Genome Resources. Human Ortholog CSF2RA, colony stimulating factor 2 receptor subunit alpha. Synonyms alphaGMR, CD116, CDw116, CSF2R, CSF2RAX, CSF2RAY, CSF2RX, CSF2RY, GMCSFR, GM-CSF-R … pho holic bolsaWebDec 3, 2015 · CSF2RA expression also reduced the stemness of RUNX1-ETO bone marrow cells and inhibited their colony forming ability. To identify which region of the receptor was mediating these pro-apoptotic effects, we generated truncation mutants and determined that the 25 amino acids at the carboxyl-terminus of the intracellular domain of CSF2RA are … how do you become thane of riften

"WebCSF2RA colony stimulating factor 2 receptor subunit alpha [ (human)] Gene ID: 1438, updated on 26-Oct-2024. Summary. The protein encoded by this gene is the alpha … " - Csf2ra

Csf2ra

WebBy using this site, you agree to our Terms and Conditions Got it! WebThe gene view histogram is a graphical view of mutations across CSF2RA. These mutations are displayed at the amino acid level across the full length of the gene by default. …

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WebMar 9, 2024 · Hereditary pulmonary alveolar proteinosis (hPAP) is a rare disorder caused by recessive mutations in GM-CSF receptor subunit α/β genes (CSF2RA/CSF2RB, respectively) characterized by impaired GM-CSF-dependent surfactant clearance by alveolar macrophages (AMs) resulting in alveolar surfactant accumulation and … WebNov 26, 2014 · Juvenile pulmonary alveolar proteinosis (PAP) due to CSF2RA mutations is a rare disorder with only a few cases described worldwide. We identified nine children …

WebAntibodies that detect CSF2RA (CD116) can be used in several scientific applications, including Western Blot, Flow Cytometry, Immunocytochemistry, Immunohistochemistry and ELISA. These antibodies target CSF2RA (CD116) in Human, Mouse and Rat samples. Our CSF2RA (CD116) monoclonal, polyclonal and recombinant monoclonal antibodies are … WebGenetic Factors. A series of reports have now established hereditary PAP as a newly described genetic disease caused by genetic mutations in CSF2RA or CSF2RB, which encode GM-CSF receptor α or β chains, respectively ( Fig. 70-3 ). 23-25,52,53 In some cases, the genes have been cloned, the defects reproduced in vitro, the signaling ...

WebColony stimulating factor 2 receptor alpha, low-affinity (granulocyte-macrophage). CD116 molecule. Back to the top. Specifications Human CSF2RA isoform_1 (pUNO1-hCSF2RAa) Genbank: NM_006140.4 with one silent variation in codon Val333 ORF size: 1203 bp Subclone: AgeI - NheI . WebThe protein encoded by this gene is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a c ytokine which controls the production, differentiation, and …

WebAntibodies that detect CSF2RA (CD116) can be used in several scientific applications, including Western Blot, Flow Cytometry, Immunocytochemistry, Immunohistochemistry … pho holic californiaWebThere is a very high volume of traffic coming from your site (IP address 40.79.131.210) as of Mon Apr 10 18:05:48 2024 (California time). So that other users get a fair share of our bandwidth, we are putting in a delay of 10.2 seconds before we service your request. how do you become thane of windhelmWebJan 5, 2024 · Orthologous to human CSF2RA (colony stimulating factor 2 receptor subunit alpha). [provided by Alliance of Genome Resources, Apr 2024] Other designations. granulocyte-macrophage colony-stimulating factor receptor subunit alpha, GM-CSF-R-alpha, GM-CSFRalpha, GMCSFR-alpha, GMR-alpha, colony stimulating factor 2 receptor … pho holic on beachWebThe granulocyte-macrophage colony-stimulating factor receptor also known as CD116 ( C luster of D ifferentiation 116 ), is a receptor for granulocyte-macrophage colony … how do you become thane of markarthWebDescription: Homo sapiens colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) (CSF2RA), transcript variant 11, non-coding RNA. RefSeq Summary (NR_027760): pho holiday menuWebJun 24, 2024 · In this larger cohort, we tested the cis-and trans effect of the four variants associated with reduced GMSI level, on gene expression of RCL1, GM-CSF signaling genes (CSF2RA, CSF2RB, JAK2 STAT5A ... how do you become that girlWebMar 29, 2024 · CSF2RA colony stimulating factor 2 receptor subunit alpha Gene ID: 1438, updated on 29-Mar-2024 Gene type: protein coding Also known as: GMR; CD116; … pho holloway road